Picomolar antimalarial agent from a Chinese medicinal plant

• 作者: Bin Zhou Flavia M.Zimbres Joshua H.Butler Cheng-Hui Xu Reagan S.Haney Yan Wu Maria B.Cassera Jian-Min Yue
• 来源期刊: 中国科学：化学（英文版）
• 年，卷（期）: 2022,（1）
• 所属期刊栏目: COMMUNICATIONS
• 页码范围: 82-86
• 页数: 5页
• 语种: 英文

摘要

In our long-term efforts searching for antimalarial agents from Chinese medicinal plants,seven novel dimeric sesquiterpenoids(1-7) with significant antimalarial activity were isolated and characterized from the whole plants of Sarcandra glabra subsp.brachystachys by solid data acquired by diverse methods.Among them,compound 3 with an ECs0 value of 4.3 pM against the chloroquine-resistant Plasmodiumfalciparum is the most potent antimalarial agent reported hitherto,about 1,000-fold stronger than artemisinin.This article further consolidates and refines our previously delineated structure-activity relationship for this antimalarial compound class.