STING1 in sepsis: Mechanisms, functions, and implications

• 作者: Zhang Ruo-Xi Kang Rui Tang Dao-Lin
• 来源期刊: 中华创伤杂志英文版
• 关键词: Sepsis STING1 Cell death Inflammation Immunity
• 年，卷（期）: 2022,（1）
• 所属期刊栏目: Review Article
• 页码范围: 1-10
• 页数: 10页
• 语种: 中文
• DOI: 10.1016/j.cjtee.2021.07.009

摘要

Sepsis is a life-threatening clinical syndrome and one of the most challenging health problems in the world. Pathologically, sepsis and septic shock are caused by a dysregulated host immune response to infection, which can eventually lead to multiple organ failure and even death. As an adaptor transporter between the endoplasmic reticulum and Golgi apparatus, stimulator of interferon response cGAMP interactor 1 (STING1, also known as STING or TMEM173) has been found to play a vital role at the intersection of innate immunity, inflammation, autophagy, and cell death in response to invading microbial pathogens or endogenous host damage. There is ample evidence that impaired STING1, through its immune and non-immune functions, is involved in the pathological process of sepsis. In this review, we discuss the regulation and function of the STING1 pathway in sepsis and highlight it as a suitable drug target for the treatment of lethal infection.