Association between the Neutrophil-to-lymphocyte Ratio and New-onset Subclinical Macrovascular and Microvascular Diseases in the Chinese Population

• 作者: WANG Jia Lu CAO Qiu Yu XIN Zhuo Jun LIU Shan Shan XU Min WANG Tian Ge LU Jie Li CHEN Yu Hong WANG Shuang Yuan ZHAO Zhi Yun XU Yu NING Guang WANG Wei Qing BI Yu Fang LI Mian
• 来源期刊: 生物医学与环境科学（英文版）
• 年，卷（期）: 2022,（1）
• 所属期刊栏目: Original Articles
• 页码范围: 4-12
• 页数: 9页
• 语种: 英文
• DOI: 10.3967/bes2022.002

摘要

Objective The association between neutrophil-to-lymphocyte ratio (NLR) with subclinicalmacrovascular and microvascular diseases has been less investigated. We sought to examine theassociation between NLR and new-onset subclinical macrovascular and microvascular abnormalities inthe Chinese population. Methods From a community cohort, we included 6,430 adults aged ≥ 40 years without subclinical macrovascular and microvascular diseases at baseline. We measured subclinical macrovascular andmicrovascular abnormalities separately using the ankle-brachial index (ABI), brachial-ankle pulse wave velocity (baPWV), and albuminuria. Results During a mean follow-up of 4.3 years, 110 participants developed incident abnormal ABI, 746 participants developed incident elevated baPWV, and 503 participants developed incident albuminuria. Poisson regression analysis indicated that NLR was significantly associated with an increased risk of new-onset abnormal ABI, elevated baPWV, and albuminuria. Compared to overweight/obese participants, we found a much stronger association between NLR and subclinical vascular abnormalities in participantswith normal weight. Furthermore, we found an interaction between the NLR and body mass index (BMI) on the risk of new-onset abnormal ABI (P for interaction: 0.01). Conclusion NLR was associated with subclinical macrovascular and microvascular diseases in theChinese population. Furthermore, in participants with normal weight, the association between NLR and subclinical vascular abnormalities was much stronger.