Maternal heterozygous mutation in CHEK1 leads to mitotic arrest in human zygotes

• 作者: Beili Chen Jianying Guo Ting Wang Qianhui Lee Jia Ming Fangfang Ding Haitao Li Zhiguo Zhang Lin Li Yunxia Cao Jie Na
• 来源期刊: 蛋白质与细胞
• 年，卷（期）: 2022,（2）
• 所属期刊栏目: LETTERS
• 页码范围: 148-154
• 页数: 7页
• 语种: 英文

摘要

Dear Editor, The first mitotic division in zygotes is crucial for the begin-ning of the life cycle for the human.After fertilization,zygotes reactivate cell cycle,both paternal and maternal genomes replicate and reprogram to become totipotent.In the mean-time,the male and female pronucleus move to the center of the zygote and merge.Then zygotes enter the metaphase,and sister chromatids separate into two daughter cells(Eckersley-Maslin et al.,2018;Reichmann et al.,2018).This is a sensitive time window and many perturbances may cause the first mitosis to fail.