Drug research and development opportunities in low-and middle-income countries: accelerating traditional medicine through systematic utilization and comprehensive synergy

• 作者: Liu Guangqi Xie Yan Sun Yinuo Zhang Kaixuan Ma Jiyan Huang Yangmu
• 来源期刊: 贫困所致传染病（英文）
• 关键词: Traditional medicine Research and development Low-and middle-income countries
• 年，卷（期）: 2022,（2）
• 所属期刊栏目: Commentary
• 页码范围: 77-80
• 页数: 4页
• 语种: 中文
• DOI: 10.1186/s40249-022-00954-4

摘要

Background::Though the utilization of traditional medicine has been proposed for modern drug research and development (R&D), limited research has discussed its feasible paths. In this commentary, we summarized key factors for new drug R&D under limited resources by reviewing China’s discovery of artemisinin, and raised suggestions to utilize traditional medicines in low-and middle-income countries (LMICs).Main text::We suggested that systematic utilization of traditional medicine, outstanding synergy of research units at all levels and timely information-sharing mechanism should be achieved to establish a comprehensive and efficient R&D system, especially under low-resource settings. In the case of artemisinin discovery, Chinese scientists integrated documented traditional medicine experiences and modern approaches to develop drug candidates timely. Due to limited R&D resources, China adopted a collaborative way, motivating nearly all domestic research units at different levels, to develop antimalarial products. Moreover, the excellent synergy among all units through efficient information-sharing mechanisms greatly avoided work repetition and accelerated the R&D process.Conclusion::Traditional medicines inspires drug discoveries in LMICs, while a comprehensive and efficient R&D system could accelerate its R&D process and save investment. The discovery of artemisinin in China gave a reliable pattern to promote sustainable development of traditional medicines and a good example to realize R&D of traditional medicine under low-resource settings.