Radio frequency(RF)devices used in modern wireless systems must meet increasingly complic-ated spectral constraints while still operating with high power efficiency.A fast real-time two-tone active load-pull algorithm is proposed to assess the relationship between nonlinear performance with associated device load impedance variations.This algorithm employs real time measurement data to extract two-tone local nonlin-ear behaviour model,which is further used for the predic-tion of injected signal value in the active real-time load-pull system,therefore minimizing the number of itera-tions required for load emulation.The proposed method was validated on a real two-tone load-pull measurement bench using off-the-shelf instruments.The result shows that the measurement speed has been greatly increased without sacrifice of the impedance emulation accuracy.This intelligent two-tone load-pull algorithm is expected to be applied in the designing of modern communication system and radar transmitters,as well as the validation of the models of radio frequency transistors.