FGF8-mediated signaling regulates tooth developmental pace during odontogenesis

• 作者: Chensheng Lin Ningsheng Ruan Linjun Li Yibin Chen Xiaoxiao Hu YiPing Chen Xuefeng Hu Yanding Zhang
• 来源期刊: 遗传学报
• 年，卷（期）: 2022,（1）
• 所属期刊栏目: Original Research
• 页码范围: 40-53
• 页数: 14页
• 语种: 英文

摘要

The developing human and mouse teeth constitute an ideal model system to study the regulatory mech-anism underlying organ growth control since their teeth share highly conserved and well-characterized developmental processes,and their developmental tempo varies notably.In the current study,we manipulated heterogenous recombination between human and mouse dental tissues and demonstrated that the dental mesenchyme dominates the tooth developmental tempo and FGF8 could be a critical player during this developmental process.Forced activation of FGF8 signaling in the dental mesenchyme of mice promoted cell proliferation,prevented cell apoptosis via p38 and perhaps PI3K-Akt intracellular signaling,and impelled the transition of the cell cycle from G1-to S-phase in the tooth germ,resulting in the slowdown of the tooth developmental pace.Our results provide compelling evidence that extrinsic signals can pro-foundly affect tooth developmental tempo,and the dental mesenchymal FGF8 could be a pivotal factor in controlling the developmental pace in a non-cell-autonomous manner during mammalian odontogenesis.