Analgesic alkaloids from Urticae Fissae Herba

• 作者: Xiaoru Feng Peijun Ju Yan Chen Xiaobo Li Mengyue Wang
• 来源期刊: 中草药（英文版）
• 年，卷（期）: 2022,（1）
• 所属期刊栏目: Original Articles
• 页码范围: 125-129
• 页数: 5页
• 语种: 英文

摘要

Objective:To investigate the analgesic substances in the aerial part of Urtica fissa(Urticae Fissae Herba),commonly used for rheumatoid and rheumatism arthritis.Methods:The analgesic constituents were isolated with the active guidance of hot plate and acetic acid writhing models,and identified by comprehensive spectroscopic analysis.Results:Thirteen alkaloids(1-13),two lignans(14,15),and three amides(16-18)were isolated from the active fractions.Among them,compound 1 was a new alkaloid,and compound 6 was a new natural prod-uct.The activity evaluation in vivo indicated that various pyrrole alkaloids(1,3,6,and 12)possessed sig-nificant analgesic activities,they could significantly inhibit the mice pain response induced by acetic acid and hot plate at the dosage of 2 mg/kg BW.Conclusion:The study revealed that the pyrrole alkaloids played important roles in the analgesic activi-ties of Urticae Fissae Herba.