Liver involvement in the course of thymoma-associated multiorgan autoimmunity: The first histological description

• 作者: Fabrizio Citarella Umberto Vespasiani-Gentilucci Anna Crescenzi Antonella Bianchi Vladimir Virzì Giuseppe Tonini
• 来源期刊: 国际肝胆胰疾病杂志（英文版）
• 年，卷（期）: 2022,（1）
• 所属期刊栏目: LETTERS TO THE EDITOR
• 页码范围: 86-89
• 页数: 4页
• 语种: 英文

摘要

To the Editor: Thymoma-associated multiorgan autoimmunity (TAMA) is a rare paraneoplastic syndrome described in patients with thymoma and characterized by multiorgan failure and graft-versus-host dis- ease (GVHD) like pathology affecting the skin, the gastrointestinal tract, and the liver. To date, only 21 cases are reported in liter- ature [1] , with some patients presenting gastrointestinal and hep- atic manifestations, mainly colitis, diarrhea, and abnormal liver en- zymes, but the hepatic involvement has not been histologically characterized yet. In the present study, we describe for the first time that liver involvement in a patient affected by TAMA resem- bles GVHD.