Three new ursane-type triterpenoids from Rosmarinus officinalis and their biological activities

• 作者: ZHONG Xiang-Jian ZHOU Na WANG Xin LI Jin-Jie MA Hui JIAO Yue XU Jia-Hui LIN Peng-Cheng SHANG Xiao-Ya
• 来源期刊: 中国天然药物
• 学科: 医学
• 年，卷（期）: 2022,（2）
• 所属期刊栏目: Research articles
• 页码范围: 155-160
• 页数: 6页
• 分类号: R284.1
• 语种: 英文
• DOI: 10.1016/S1875-5364(21)60103-6

摘要

Three new ursane-type triterpenoids,3-oxours-12-en-20,28-olide(1),3β-hydroxyurs-12-en-20,28-olide(2)and 3β-hy-droxyurs-11,13(18)-dien-20,28-olide(3),were isolated from a potent anti-inflammatory and antibacterial fraction of the ethanolic ex-tract of Rosmarinus officinalis.Their structures were elucidated by a combination of extensive 1D-and 2D-NMR experiments,MS data and comparisons with literature reports.Compounds 1-3 exhibited significantly inhibitory effects on nitric oxide production in lipopolysaccharide-activated mouse RAW264.7 macrophages,but no antibacterial activity was found at a concentration of 128 μg·mL-1.