Hybeanones A and B,Two Highly Modified Polycyclic Polyprenylated Acylphloroglucinols from Hypericum beanii

• 作者: Beiye Yang Changxing Qi Zeyu Yao Shuang Lin Fengli Li Weiguang Sun Zhengxi Hu Yonghui Zhang
• 来源期刊: 中国化学（英文版）
• 年，卷（期）: 2022,（1）
• 所属期刊栏目: Concise Reports
• 页码范围: 53-58
• 页数: 6页
• 语种: 英文
• DOI: 10.1002/cjoc.202100468

摘要

Hybeanones A and B (1 and 2),two highly oxygenated and rearranged polycyclic polyprenylated acylphloroglucinols (PPAPs),were isolated from the aerial parts of Hypericum beanii.Their structures comprising absolute configurations were elucidated by spectro-scopic analysis,single-crystal X-ray diffraction,and quantum chemical calculations.Compounds 1.and 2 are defined by a newly as-sembled cyclopentanone unit fused to a tricyclic γ-lactone unit via a ketone carbonyl.The breakage of C-1/C-2 linkage via ret-ro-Claisen reaction,attack from C-1 to C-19,and Baeyer-Villiger oxidation at C-1/C-23 bond were presumed to be the key steps in the assembly of 1 and 2.The isolates 1 and 2 showed potential acetylcholinesterase (AchE) inhibitory activities,with ICs0 values of 21.34± 1.48 and 18.79 ±2.36 μmol/L,respectively.