Decoding the intercellular communication network during tumorigenesis

• 作者: Liwei An Ruixian Yu Yi Han Zhaocai Zhou
• 来源期刊: 癌症生物学与医学（英文版）
• 年，卷（期）: 2022,（3）
• 所属期刊栏目: EDITORIAL
• 页码范围: 265-272
• 页数: 8页
• 语种: 英文
• DOI: 10.20892/j.issn.2095-3941.2021.0558

摘要

Under physiological conditions, decisions about cell fate and behavior are not made by the individual cell itself, but instead strictly depend on the collective interactions of the whole cell population in the microenvironment. Thus, continuous intercellular communication influences almost all biological processes ranging from tissue/organ development, and home-ostasis maintenance, to disease progression. Regarding tumori-genesis, intercellular communications between cancer cells and other cells coexist within microenvironments involving stromal cells, immune cells, and even neural cells, playing crucial roles in tumor initiation, progression, and distal metastasis. Thus, a detailed understanding of cell-cell interactions within the tumor microenvironment facilitates mechanistic delineation of tumorigenesis, and also may identify promising cell-cell inter-action targets to treat cancer.