Transition-Metal-Free Catalyzed Dehydrative Coupling of Quinoline and Isoquinoline N-Oxides with Propargylic Alcohols

• 作者: Zhao-Nan Cai Xiang-Xuan Feng Yuecheng Zhang Cong-Cong Lu Ya-Ping Han Jiquan Zhao
• 来源期刊: 中国化学（英文版）
• 年，卷（期）: 2022,（1）
• 所属期刊栏目: Concise Reports
• 页码范围: 71-78
• 页数: 8页
• 语种: 英文
• DOI: 10.1002/cjoc.202100687

摘要

A novel,green,and transition-metal-free protocol for the facile modification of quinoline and isoquinoline derivatives is introduced,starting from readily available and environmentally benign quinoline and isoquinoline N-oxides with propargylic alcohols in the presence of Na2S2O8 or K2S2O8 at 100 ℃.The one-pot transformation features the advantages of good functional group compatibility,short reaction time,operational simplicity,and highly efficient reaction system.This protocol,which produces water as the only by-product,provides efficient and atom-economical access to a class of fascinating quinoline and isoquinoline products in satisfactory yields.The method is effective on the gram scale,thus highlighting the inherent practicality of this methodology.