Xishaglaucumins A-J,New Cembranoids with Anti-Inflamma-tory Activities from the South China Sea Soft Coral Sarcophyton glaucum

• 作者: Jin-Feng Li Yan-Bo Zeng Wang-Sheng Li Hui Luo Hai-Yan Zhang Yue-Wei Guo
• 来源期刊: 中国化学（英文版）
• 年，卷（期）: 2022,（1）
• 所属期刊栏目: Concise Reports
• 页码范围: 79-90
• 页数: 12页
• 语种: 英文
• DOI: 10.1002/cjoc.202100564

摘要

Ten new cembrane-type diterpenoids,namely xishaglaucumins A-J (1-10),along with ten known related ones (11-20),have been isolated from the soft coral Sarcophyton glaucum collected off the Xisha Island in the South China Sea.Their structures were eluci-dated by extensive spectroscopic analysis,quantum mechanical nuclear magnetic resonance (QM-NMR) methods,X-ray diffraction analysis,chemical methods and comparison with the reported data in the literature.The absolute configuration of new compounds 1,5 and known compounds 11,12,16 and 20 were determined either by chemical methods or by X-ray diffraction analysis using Cu Kα (λ =1.5417 (A)).In in vitro bioassay,compound 4 exhibited inhibitory effects on lipopolysaccharide (LPS)-induced inflammatory responses in BV-2 microglial cells.