It's just a phase:NLRP6 phase separations drive signaling

• 作者: Rebecca E.Tweedell Thirurnala-Devi Kanneganti
• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2022,（2）
• 所属期刊栏目: RESEARCH HIGHLIGHTS
• 页码范围: 113-114
• 页数: 2页
• 语种: 英文

摘要

NLRP6 is a key innate immune sensor whose functions have remained understudied.In a recent Cell paper,Shen et al.evaluate the mechanism of NLRP6 activation and find that double-stranded RNA interacts with NLRP6 and leads to liquid-liquid phase separation that is critical for NLRP6-dependent innate immune signaling.