Cobalt-Catalyzed Enantioselective Ring-Opening Reactions of Oxa-and Aza-bicyclic Alkenes with Alkenylboronic Acids

• 作者: Di Zhu Yongmei Zhao Qinglei Chong Fanke Meng
• 来源期刊: 中国化学（英文版）
• 年，卷（期）: 2022,（2）
• 所属期刊栏目: Concise Reports
• 页码范围: 190-194
• 页数: 5页
• 语种: 英文
• DOI: 10.1002/cjoc.202100622

摘要

Catalytic enantioselective ring-opening of oxa-and aza-bicyclic alkenes with readily available accessible alkenylboronic acids,pro-moted by a chiral phosphine-Co complex,is reported.Such a process represents the unprecedented Co-catalyzed introduction of various alkenyl groups onto the oxa-and aza-bicyclic alkenes,affording a wide range of multisubstituted functionalized cyclohexenes in up to 98％ yield and 99.5 :0.5 er.