Ineffectiveness of Skin Tests in Predicting Allergic Reactions Induced by Chinese Herbal Injections

• 作者: LYU Chun-xiao ZHANG Jun-hua WANG Bao-he ZHANG Bo-li LIU Chang-xiao LI Yan-fen HUANG Yu-hong
• 来源期刊: 中国结合医学杂志（英文版）
• 年，卷（期）: 2022,（1）
• 所属期刊栏目: Original Articles
• 页码范围: 36-42
• 页数: 7页
• 语种: 英文
• DOI: 10.1007/s11655-021-3523-2

摘要

Objective:To evaluate whether skin tests are suitable to predict the allergy reactions induced by Chinese herbal injections (CHIs).Methods:The skin tests including skin prick tests (SPT),intradermal tests (IDT)and provocation tests including subcutaneous tests and intravenous tests were administered to 249 healthy subjects and 180 allergic patients for 3 CHIs,including ginkgolide injection,diterpene ginkgolide meglumine injection and Salvianolate lyophilized injection.The results of the provocation tests were used as the "gold standard" to determine the sensitivity and specificity of the skin tests.Results:The results did not show any significant differences between the healthy and allergy groups in both skin tests and provocation tests (P＞0.05).The specificities of SPT and IDT were 0.976 and 0.797,respectively,and the sensitivities of both SPT and IDT were 0.Conclusion:Skin tests are insufficient to predict the likelihood of allergic reactions resulting from CHIs.(ChiCTR-CPC-15006921)