An imported Genotype D Coxsackievirus B4 Strain Identified in Tianjin, China

• 作者: TAN Zhao Lin LYU Li Kun XIE Tong LI Li LI Xiao Yan
• 来源期刊: 生物医学与环境科学（英文版）
• 年，卷（期）: 2022,（3）
• 所属期刊栏目: Letters to the Editor
• 页码范围: 239-247,前插23
• 页数: 10页
• 语种: 英文
• DOI: 10.3967/bes2022.033

摘要

Hand, foot, and mouth disease (HFMD) is an infectious disease caused by various enterovirus (EV) serotypes and occurs in infants and children across the world. The mild symptoms of HFMD include fever and a maculopapular rash on the hands, feet, mouth, and buttocks. However, in some patients, this infection causes severe neurological syndromes and even death. EVs belong to the Enterovirus genus (family Picornaviridae, order Picornavirales), of which there are 15 species: Enterovirus A (EV-A), EV-B, EV-C, EV-D, EV-E, EV-F, EV-G, EV-H, EV-I, EV-J, EV-K, EV-L, Rhinovirus A, Rhinovirus B, and Rhinovirus C. Since the 2008 outbreaks, enterovirus 71 (EV-A71) and coxsackievirus A16 (CVA16) have been considered to be the two major HFMD pathogens in China[1]. Nevertheless, other prevalent EV serotypes have caused large-scale outbreaks (e.g., CVA4, CVA6, CVA10, and Echovirus 11). Therefore, increasing attention has recently shifted to other EV-A and EV-B pathogens to determine the spectrum of HFMD-causing pathogens besides the major causative ones.