Construction of Chiral All-Carbon Quaternary Stereocenters by Asymmetric Friedel-Crafts Reaction of Isatin Derivatives

• 作者: Jindong Li Wenjing Lu Yangmian Lu Zhenggen Zha Zhiyong Wang
• 来源期刊: 中国化学（英文版）
• 年，卷（期）: 2022,（2）
• 所属期刊栏目: Concise Reports
• 页码范围: 195-200
• 页数: 6页
• 语种: 英文
• DOI: 10.1002/cjoc.202100696

摘要

Under the catalysis of chiral Cu(Ⅱ) complex,C2 and C3 alkylation of pyrrole and C3 alkylation of indole were realized simultaneously.The chiral oxindole skeleton with an all-carbon quaternary stereogenic center at the C3-position could be obtained exclusively with high yields (up to 95％) and excellent enantioselectivities (up to ＞ 99％).