The Wnt/β-catenin signaling pathway in the tumor microenvironment of hepatocellular carcinoma

• 作者: Kaiting Wang Xinyao Qiu Yan Zhao Hongyang Wang Lei Chen
• 来源期刊: 癌症生物学与医学（英文版）
• 年，卷（期）: 2022,（3）
• 所属期刊栏目: REVIEW
• 页码范围: 305-318
• 页数: 14页
• 语种: 英文
• DOI: 10.20892/j.issn.2095-3941.2021.0306

摘要

The Wnt/β-catenin signaling pathway regulates many aspects of tumor biology, and many studies have focused on the role of this signaling pathway in tumor cells. However, it is now clear that tumor development and metastasis depend on the two-way interaction between cancer cells and their environment, thereby forming a tumor microenvironment (TME). In this review, we discuss how Wnt/β-catenin signaling regulates cross-interactions among different components of the TME, including immune cells, stem cells, tumor vasculature, and noncellular components of the TME in hepatocellular carcinoma. We also investigate their preclinical and clinical insights for primary liver cancer intervention, and explore the significance of using Wnt/β-catenin mutations as a biomarker to predict resistance in immunotherapy.