SPFH protein cage — one ring to rule them all

• 作者: Oliver Daumke Gary R.Lewin
• 来源期刊: 细胞研究（英文版）
• 年，卷（期）: 2022,（2）
• 所属期刊栏目: RESEARCH HIGHLIGHTS
• 页码范围: 117-118
• 页数: 2页
• 语种: 英文

摘要

Stomatin/prohibitin/flotillin/HflKC (SPFH) proteins comprise a universally conserved family of membrane-associated scaf-folds that compartmentalize membranes,but the detailed molecular mechanism has remained unclear.In a recent paper published in Cell Research,Ma et al.determined the cryo-EM structure of the bacterial SPFH heterodimer HflK/C,which assembles into a giant molecular cage encasing four AAA+protease hexamers;the structural work elucidates how SPFH proteins confine their client proteins in specialized membrane microdomains.