Influence of Acupuncture on Microcirculation Perfusion of Pericardium Meridian and Heart in Acute Myocardial Ischemia Model Rats

• 作者: ZHUANG Yi ZHOU Jie ZHOU Yu-mei CHEN Jiao WU Ping LYU Pei-ran WAN Min LUO Liao-jun CAI Ding-jun LIANG Fan-rong
• 来源期刊: 中国结合医学杂志（英文版）
• 年，卷（期）: 2022,（1）
• 所属期刊栏目: Acupuncture Research
• 页码范围: 69-75
• 页数: 7页
• 语种: 英文
• DOI: 10.1007/s11655-021-3294-9

摘要

Objective:To observe the influence of acupuncture on microcirculation perfusion of the pericardium meridian and heart in acute myocardial ischemia (AMI) rats and evaluate whether acupuncture can simultaneously affect the meridians and corresponding viscera.Additionally,acupoints at different meridians were compared and whether they exert the same effects was discussed.Methods:Totally 32 Sprague-Dawley rats were subjected to left anterior descending (LAD) ligation to develop an AMI model.Rats were divided into 4 groups,including AMI,acupuncture Neiguan (PC 6),Lieque (LU 7) and Qiansanli(LI 10) groups (n=8).Eight rats received only thoracotomy (sham-operated group).The rats in the acupuncture groups received manual acupuncture at PC 6,LU 7 and LI 10 acupoints for 15 min,respectively.The microcirculation perfusion of pericardium meridian and heart was monitored by laser speckle peffusion imager(LSPI) before,during and after acupuncture manipulation for 15 min.Subsequently,the perfusion unit (PU)was calculated and analyzed by PSI System.Results:After LAD,compared to pre-acupuncture stage,the heart microcirculation perfusion (HMP) in the AMI group decreased continuously at during-acupuncture (P＞0.05) and post-acupuncture stages (P＜0.05),and the pericardium meridian microcirculation perfusion (PMP) showed no significant differences at 3 stages (P＞0.05).Compared to pre-acupuncture stage,the PMP and HMP in PC 6 group significantly increased during acupuncture manipulation (both P＜0.05),and PMP decreased obviously after acupuncture (P＜0.05).The PMP in the LU 7 and LI 10 groups were slightly elevated (both P＞0.05);however,they were significantly reduced after acupuncture manipulation (both P＜0.05).Additionally,HMP of LI 10 group was decreased significantly during acupuncture,especially compared to pre-acupuncture stage(P＜0.05).Conclusions:Acupuncture at PC 6 obviously increased the PMP and HMP in AMI rats,and the effects were superior to at LU 7 and LI 10 acupoints.It was further confirmed that acupuncture promoted qi and blood circulation,indicating that acupoint specificity exists and features a meridian-propagated effect.