Syntheses,Crystal Structures,Anticancer Activities and DNA-Binding Properties of the Dibutyltin Complexes Based on Benzoin Aroyl Hydrazone

• 作者: JIANG Wu-Jiu TAN Yu-Jun MAN Jia-Tai TAN Yu-Xing
• 来源期刊: 结构化学
• 年，卷（期）: 2022,（2）
• 所属期刊栏目: medicinal structural chemistry
• 页码范围: 105-113
• 页数: 9页
• 语种: 英文
• DOI: 10.14102/j.cnki.0254-5861.2011-3246

摘要

Dibutyltin benzoin benzoyl hydrazone complex Ⅰ[C6H5(O)C=N-N=C(Ph)CH(Ph)O]2[(n-Bu)2Sn]2 and dibutyltin benzoin salicyl hydrazone complex Ⅱ[2-(OH)-C6H4(O)C=N-N=C(Ph)CH(Ph)O]2[(n-Bu)2Sn]2 were synthesized and characterized by IR,1H,13C and 119Sn NMR spectra,HRMS,elemental analysis and thermal stability analysis,and the crystal structures were determined by X-ray diffraction.The crystal of complexⅠ belongs to monoclinic system,space group P21/n with a =11.1942(8),b =10.4754(7),c =23.6700(17) (A),β =101.529(2)°,Z =2,V=2719.6(3) (A)3,Dc =1.371 Mg·m-3,μ(MoKα) =0.966 mm-1,F(000) =1152,R =0.0458 and wR =0.1312.The crystal of complex Ⅱ is of triclinic system,space group P(-1) with a =9.9960(4),b =11.2466(4),c =14.0509(5) (A),α =69.4190(10)°,β=70.0600(10)°,γ =81.8090(10)°,Z =1,V=1389.69(9) (A)3,Dc =1.380 Mg·m-3,μ(MoKα) =0.950 mm-1,F(000) =592,R =0.0284 and wR =0.0690.In vitro antitumor activities of both complexes were evaluated by CCK8 method against three human cancer cell lines (MCF7,NCI-H460 and HepG2),and complex Ⅱ exhibited better antitumor activity than Ⅰ.The interaction between complexes and calf thymus DNA was studied by UV-vis,fluorescence spectroscopy and viscosity measurements.