Access to chiral homoallylic vicinal diols from carbonyl allylation of aldehydes with allyl ethers via palladium-catalyzed allylic C-H borylation

• 作者: Tian-Ci Wang Pu-Sheng Wang Dian-Feng Chen Liu-Zhu Gong
• 来源期刊: 中国科学：化学（英文版）
• 年，卷（期）: 2022,（2）
• 所属期刊栏目: COMMUNICATIONS
• 页码范围: 298-303
• 页数: 6页
• 语种: 英文

摘要

Chiral homoallylic vicinal diols are found in many bioactive compounds and are among the most versatile functional groups in organic chemistry.Here,we describe an asymmetric carbonyl allylation of aldehydes with allyl ethers proceeding via allylic C-H borylation enabled by palladium and chiral phosphoric acid sequential catalysis,providing facile access to homoallylic vicinal anti-diols in high yields and with excellent stereoselectivity.This protocol enables the total synthesis of aigialomycin D to be finished within 7 steps.