Synthesis and Antibacterial Activity of Selenium-functionalized Poly(ε-caprolactone)

• 作者: Ying-Ying Li Dong Xing Xiang-Qiang Pan Jian Zhu
• 来源期刊: 高分子科学（英文版）
• 年，卷（期）: 2022,（1）
• 所属期刊栏目: RESEARCH ARTICLES
• 页码范围: 67-74
• 页数: 8页
• 语种: 英文

摘要

A selenium-functionalized ε-caprolactone was synthesized by introducing a phenyl selenide group at the 7-position.A polymer was obtained through the ring-opening polymerization of this monomer in a base/thiourea binary organocatalytic system.A living polymerization process was achieved under mild conditions.The resulting polymers had a controlled molecular weight with a narrow molecular weight distributions and high end-group fidelity.Random copolymers could be obtained by copolymerizing this monomer with ε-caprolactone.The thermal degradation temperature of the obtained copolymers decreased with the increasing molar ratio of selenide functionalized monomer in copolymers,while the glass transition temperature increased.In addition,the phenyl selenide side group could be further modified to a polyselenonium salt,which resulted in a polymer with good antibacterial properties.The survival rate of E.coli and S.aureus was only 9％ with a polymer concentration of 62.5 μg/mL.