Mechanisms of Acupuncture in Improving Alzheimer's Disease Caused by Mitochondrial Damage

• 作者: JIANG Yu-hang HE Jia-kai LI Ran CHEN Ze-hao JIA Bao-hui
• 来源期刊: 中国结合医学杂志（英文版）
• 年，卷（期）: 2022,（3）
• 所属期刊栏目: Reviews
• 页码范围: 272-280
• 页数: 9页
• 语种: 英文
• DOI: 10.1007/s11655-022-3511-6

摘要

Alzheimer's disease(AD)is one of the most common neurodegenerative diseases among the elderly and it accounts for nearly 80％of all dementias.The pathogenesis of AD is complicated and enigmatic thus far.The mitochondrial cascade hypothesis assumes that mitochondrial damage may mediate,drive,or contribute to a variety of AD pathologies and may be the main factor in late-onset AD.Currently,there are no widely recognized drugs able to attenuate mitochondrial damage in AD.Notably,increasing evidence supports the efficacy of acupuncture for improving the mitochondrial structure and protecting mitochondrial functions in AD.This review reports the mechanisms by which acupuncture regulates mitochondrial dynamics,energy metabolism,calcium homeostasis and apoptosis.In conclusion,these findings suggest that AD mitochondrial dysfunction represents a reasonable therapeutic target and acupuncture could play a significant role in preventing and treating AD.