Gut Microbiota Diversity and Overweight/Obesity in Infancy:Results from a Nested Case-control Study

• 作者: Hong MEI Neng LI Yan ZHANG Dan ZHANG An-na PENG Ya-fei TAN Hui MEI Han XIAO Jiang-xia CAO Jie-qiong ZHOU Yuan-yuan ZHONG Rui-zhen LI Shao-ping YANG
• 来源期刊: 当代医学科学（英文）
• 年，卷（期）: 2022,（1）
• 所属期刊栏目: ORIGINAL ARTICLES
• 页码范围: 210-216
• 页数: 7页
• 语种: 英文
• DOI: 10.1007/s11596-021-2476-1

摘要

Objective:Childhood obesity is a major health concern worldwide.Previous studies have explored the relationship between obesity and gut microbiota.However,the results from such studies remain contradictory.Methods:In the present nested case-control study,based on a twin birth cohort study,the relationship between gut microbiota diversity and overweight/obesity in 1-and 6-month-old infants was explored.Twins were enrolled when one child had normal weight and the other child was overweight/obese at six months old.For both infants,stool samples were collected at 1 and 6 months of age.Finally,12 twins were enrolled in the study.The gut microbiota was identified by 16S rRNA gene sequencing in the V3-V4 area.Six of the twins were monozygotic.Results:The results revealed that the microbiota communities of monozygotic twins were similar to those of dizygotic twins.The relative abundance(RA)of microbiota of 1-month-old twins was significantly higher than that of 6-month-old twins.However,the microbiota diversity of 1-month-old twins was significantly lower than that of 6-month-old twins.In addition,6-month-old twins had significantly higher RA levels of Bifidobacterium and Lachnospiracea incertae sedis than 1-month-old twins.The 6-month-old group had significantly lower RA levels of Veillonella,Klebsiella,Akkermansia,Streptococcus,or Staphylococcus than the 1-month-old group.At six months,the RA level of Clostridium sensu stricto was higher in the overweight/obesity group than the normal-weight group.Conclusion:These findings imply that changes in gut microbiota diversity during infancy may contribute to the development of obesity in early infancy.