Wearable strain sensors are arousing increasing research inter-ests in recent years on account of their potentials in motion detection,per-sonal and public healthcare,future entertainment,man-machine interaction,artificial intelligence,and so forth.Much research has focused on fiber-based sensors due to the appealing performance of fibers,including processing flex-ibility,wearing comfortability,outstanding lifetime and serviceability,low-cost and large-scale capacity.Herein,we review the latest advances in func-tionalization and device fabrication of fiber materials toward applications in fiber-based wearable strain sensors.We describe the approaches for prepar-ing conductive fibers such as spinning,surface modification,and structural transformation.We also introduce the fabrication and sensing mechanisms of state-of-the-art sensors and analyze their merits and demerits.The applica-tions toward motion detection,healthcare,man-machine interaction,future entertainment,and multifunctional sensing are summarized with typical examples.We finally critically analyze tough challenges and future remarks of fiber-based strain sensors,aiming to implement them in real applications.