Metal-Free Synthesis of Benzo[α]phenanthridines from Aromatic Aldehydes,Cyclohexanones,and Aromatic Amines

• 作者: Pingyu Jiang Zhifei Shan Shanping Chen Quanyuan Wang Shuxin Jiang Haolin Zheng Guo-Jun Deng
• 来源期刊: 中国化学（英文版）
• 年，卷（期）: 2022,（3）
• 所属期刊栏目: Concise Reports
• 页码范围: 365-370
• 页数: 6页
• 语种: 英文
• DOI: 10.1002/cjoc.202100670

摘要

A three-component synthesis of benzo[α]phenanthridines from aromatic aldehydes,cyclohexanones,and aromatic amines has been developed,which is mediated by KI/DMSO/camphorsulfonic acid to afford a variety of functionalized benzo[α]phenanthridines in satisfactory yields.The present strategy provides a biaryl motif ortho to the nitrogen atom which has the potential to be used as lig-and by further modification.With the advantages of readily available starting materials,transition-metal-free conditions,gram-scale synthesis,and broad substrate scope,this three-component protocol provides an efficient approach for the preparation of diverse benzo[α]phenanthridines.