Caffeine Exposure Causes Immune Dysfunction and Intrauterine Growth Restriction Retardation in Rats

• 作者: ZHANG Wen Zhong SUN Na Na HU Yang CAO Yu Amber Sheeks
• 来源期刊: 生物医学与环境科学（英文版）
• 年，卷（期）: 2022,（2）
• 所属期刊栏目: Letters to the Editor
• 页码范围: 170-173
• 页数: 4页
• 语种: 英文
• DOI: 10.3967/bes2022.025

摘要

This study was conducted to assess the effects of caffeine on the dam and the physical development of rat offspring. Pregnant Sprague-Dawley rats (20 per dose group) were administered caffeine by gavage at 0 (control), 5, 20, and 80 mg/kg body weight (bw) daily from gestational day 6 through lactation using caffeine dissolved in water. The developmental toxicity of caffeine was evaluated. Dams in the 80 mg/kg bw group exhibited splenic atrophy.