Core-shell nanostructures constituted by a plasmonic core and an ultrathin shell have drawn enormous attentions in enhanced spectroscopies,catal-ysis,energy,and other fields because of their splendid properties such as multifunctionality,stability,and adjustability.In this article,we summarized the endeavors made by our group in the past decade about the core-shell nanostructures in the shell-isolated nanoparticle-enhanced Raman spec-troscopy(SHINERS)and plasmon-enhanced spectroscopies.Meanwhile,the potential challenges and perspectives about core-shell nanostructures in spectroscopies have also been proposed.Thus,we believe this article would provide an avenue for a comprehensive understanding of enhanced spectroscopies with core-shell nanostructures.