Significance of preoperative fibrinogen levels, neutrophils-to-lymphocyte ratio and its combined scores in evaluating the prognosis of postoperative patients with gastric cancer

• 作者: Jian-Zhong Deng Xiu-Ling Liu Qian Liu Wen-Jing Li Wen-Bin Lu
• 来源期刊: 海南医科大学学报（英文版）
• 年，卷（期）: 2022,（5）
• 所属期刊栏目: Original article
• 页码范围: 29-33
• 页数: 5页
• 语种: 英文

摘要

Objective:To investigate the clinic significance of the combined detection of peripheral fibrinogen (Fbg) and neutrophils-to-lymphocyte ratio (NLR) (F-NLR) on the prognosis of postoperative gastric cancer patients. Methods: The clinical and pathological characteristics of 70 gastric cancer patients who were diagnosed by gastroscopy and surgically resected were collected, and the relationship between Fbg, NLR and F-NLR scores and pathological characteristics and prognosis of gastric cancer patients was retrospectively analyzed. Results: There were statistically significant differences in the levels of NLR in gastric cancer patients of different genders (P < 0.05), while there were no significant differences in the levels of NLR and Fbg in other pathological factors such as age, T stage, lymph node metastasis and TNM stage(P > 0.05). The f-NLR score of gastric cancer patients with different gender, T stage and TNM stage had statistical significance (P < 0.05), but there was no statistical significance in the F-NLR score of gastric cancer patients with different age and whether lymph node metastasis (P > 0.05). Univariate analysis showed that Fbg, NLR, F-NLR score, and TNM stage had an effect on recurrence and survival of patients with gastric cancer after surgery (P <0.05); multivariate COX regression analysis showed that only F-NLR score and TNM stage were independent risk factors for relapse and survival of patients with gastric cancer (P <0.05). Conclusion: The F-NLR scores about the combined detection of Fbg and NLR may guide clinical prediction of the prognosis of gastric cancer patients.