Analysis of the law of traditional Chinese medicine in prevention and treatment of gastrointestinal reaction caused by lung cancer chemotherapy

• 作者: Yue-Jie Lin Yue Luo Lu-Yao Wang Pei-Tong Zhang
• 来源期刊: 海南医科大学学报（英文版）
• 年，卷（期）: 2022,（5）
• 所属期刊栏目: Original article
• 页码范围: 34-40
• 页数: 7页
• 语种: 英文

摘要

Objective: To explore the law of traditional Chinese medicine in prevention and treatment of gastrointestinal reaction after chemotherapy for lung cancer. Methods: The literatures on prevention and treatment of gastrointestinal reaction after chemotherapy with Chinese medicine were searched from CNKI, Wanfang and VIP databases from the establishment of the database to September 2020. After screening, the database was established, and data mining was conducted by using IBM SPSS statistics 20.0 and IBM SPSS modeler 18.0 to summarize the medication rules of traditional Chinese medicine in the prevention and treatment of gastrointestinal reaction after chemotherapy for lung cancer. Results: (1) A total of 131 literatures involving 245 traditional Chinese medicines were included for data mining; (2) High frequency drugs include Astragalus membranaceus, liquorice, Poria cocos, Atractylodes macrocephala, Pinellia ternata, Codonopsis pilosula, Ophiopogon japonicus, coix seed, Pericarpium Citri Reticulatae, Radix Glehniae and so on; (3)The traditional Chinese medicine used is mainly tonifying deficiency medicine, resolving phlegm and relieving cough and asthma medicine, diuresis and dampness medicine, heat clearing medicine and antiphlogistic medicine. The medicine tastes bitter and sweet, and has cold and warm properties. The meridian tropism involves liver, lung, stomach, spleen and kidney;(4) Seven core TCM combinations were obtained by cluster analysis, and 24 drug pairs (groups) were obtained by association rule analysis. Conclusion: Through the data mining of traditional Chinese medicine for the prevention and treatment of gastrointestinal reaction after chemotherapy for lung cancer, we can find out the potential rules of traditional Chinese medicine prescription, and clarify the core Chinese medicine, which is helpful to provide certain reference for the development and research of drugs for the treatment of gastrointestinal reaction and modern clinical practice.