Zwitterionic-phosphonate block polymer as anti-fouling coating for biomedical metals

• 作者: Ya-Hui Gu Hong-Wei Liu Xiao-Han Dong Zhuang-Zhuang Ma You-Xin Li Li Li Dong-Lin Gan Ping-Sheng Liu Jian Shen
• 来源期刊: 稀有金属（英文版）
• 年，卷（期）: 2022,（2）
• 所属期刊栏目: SPECIAL TOPIC:ANTIBACTERIAL MATERIALS
• 页码范围: 700-712
• 页数: 13页
• 语种: 英文

摘要

Antifouling ability and blood compatibility are critically important in the development of medical metallic implants for clinical applications.Here,we report the zwitterionic-phosphonate block polymer as a new type of high-efficiency antifouling coating for metallic substrates.Six block polymers (pSBMA-b-pDEMMP) with different segment lengths (nSBMA∶ nDEMMP =10∶25,40∶25,100∶25,75∶5,75∶40,75∶100) were prepared and anchored on tita-nium alloy (TC4) substrates.1H nuclear magnetic reso-nance (NMR) results clearly showed the precise preparation of the block polymers.XPS analysis and water contact angle measurement indicated the successful con-struction of the block polymer on TC4 substrates.The relationship between the antifouling performance of the polymer coating and the length of pDEMMP and pSBMA segments in the block polymer was established.Results showed that the polymer containing the pSBMA segment above 40 repeat units could significantly inhibit protein adsorption,platelet adhesion,bacterial adhesion and cell adhesion,while the pDEMMP segment above 5 repeat units is able to generate stable zwitterionic polymer coating on TC4 substrates.This ease of production and high-effi-ciency antifouling modification strategy elucidated here may find broad application for biomedical implants and devices in clinical applications.