Diverse Ring-seco Limonoids from Munronia unifoliolata and Their Biological Activities

• 作者: Yunpeng Sun Qiurong Li Letian Cui Pengfei Tang Yongyi Li Lingyi Kong Jun Luo
• 来源期刊: 中国化学（英文版）
• 年，卷（期）: 2022,（1）
• 所属期刊栏目: Comprehensive Reports
• 页码范围: 123-136
• 页数: 14页
• 语种: 英文
• DOI: 10.1002/cjoc.202100717

摘要

Twenty-two new limonoids,mufolinoids A-V (1-22),including six rings A,B-seco limonoids (1-6),twelve ring A-seco limonoids(7-18),four ring-intact limonoids (19-22),together with thirteen known compounds (23-35) were isolated from Munronia unifo-liolata.Their structures including absolute configurations were elucidated by combination of NMR,HR-MS,single-crystal X-ray dif-fraction and calculations of ECD and NMR technologies.Compounds 24,25,33,34 could be significantly reversed the multidrug re-sistance of MCF-7/doxorubicin (DOX) cells,and the reversal fold (RF) was much higher than that of positive drug Verapamil.Com-pounds 24,28,and 29 exhibited significant anti-inflammatory activity with the ICs0 values in the range of 17.7-39.4 μmol/L.Fur-thermore,compound 29 could markedly inhibit the release of IL-1β by inhibiting the initiation and assembly of NLRP3 inflam-masome,which demonstrates the great potential of limonoids as an anti-inflammatory agent.