Peptide or Protein-Protected Metal Nanoclusters for Therapeutic Application

• 作者: Xiaolei Chen Xiaojun Ren Xueyun Gao
• 来源期刊: 中国化学（英文版）
• 年，卷（期）: 2022,（2）
• 所属期刊栏目: Chemistry Authors Up Close
• 页码范围: 267-274
• 页数: 8页
• 语种: 英文
• DOI: 10.1002/cjoc.202100523

摘要

Metal nanoclusters have attracted much attention due to their ultra-small size and unique properties.The integration of protein or peptide can bring a synergistic effect on the physicochemical and physiological properties of metal clusters.Metal nanoclusters protected by peptides or proteins ex-hibit excellent biocompatibility and better disease therapeutic effects.We focus on developing new metal nanoclusters and exploring their therapeu-tic mechanism,including inhibiting enzyme activity,mitochondrial dysfunction,DNA strand break,and block of the signal pathway.