Cationic and Anionic Antimicrobial Agents Co-Templated Mesostructured Silica Nanocomposites with a Spiky Nanotopology and Enhanced Biofilm Inhibition Performance

• 作者: Yaping Song Qiang Sun Jiangqi Luo Yueqi Kong Bolin Pan Jing Zhao Yue Wang Chengzhong Yu
• 来源期刊: 纳微快报（英文版）
• 年，卷（期）: 2022,（5）
• 页码范围: 244-254
• 页数: 11页
• 语种: 英文

摘要

Silica-based materials are usually used as delivery systems for antibacterial applications.In rare cases,bactericidal cationic surfactant templated silica composites have been reported as antimicrobial agents.However,their anti-bacterial efficacy is limited due to limited control in content and structure.Herein,we report a"dual active templating"strat-egy in the design of nanostructured silica composites with intrinsic antibacterial per-formance.This strategy uses cationic and anionic structural directing agents as dual templates,both with active antibacterial property.The cationic-anionic dual active templating strategy further contributes to antibacterial nanocomposites with a spiky surface.With controllable release of dual active antibacterial agents,the spiky nanocomposite displays enhanced anti-microbial and anti-biofilm properties toward Staphylococcus epidermidis.These findings pave a new avenue toward the designed synthesis of novel antibacterial nanocomposites with improved performance for diverse antibacterial applications.