Changes of activity of liver glycogen synthase in experimental diabetes mellitus rats

• 作者: Ma Xiaowei Qian Rongli Wang Yanrong
• 来源期刊: CHINESE MEDICAL JOURNAL
• 年，卷（期）: 1998,（1）
• 所属期刊栏目: Original Article
• 页码范围: 32-34
• 页数: 3页
• 语种: 中文

摘要

OBJECTIVETo study the activity of liver glycogen synthase in analogous model of NIDDM rats.METHODSMale Wistar rats were injected with low dose of streptozotocin (STZ) (30 mg/kg body weight) via tail vena and those animals with glucose tolerance impaired and level of insulin equal to or higher than that of the controls at 18th week were taken as the analogous rat model of NIDDM. The activity of liver glycogen synthase (GS) was assayed at the end of experiment.RESULTSType I-enzyme: 0.18±0.06 mumol/min.g versus 0.24±0.09 mumol/min.g, P<0.05, and total-enzyme: 1.52±0.43 mumol/min. g versus 1.84±0.42 mumol/min.g, P<0.05.CONCLUSIONSThe GS activity of diabetic rats was significantly lower than that of control.