人胎盘提取物对大鼠伤口愈合的作用

• 作者: AUDDY Biswajit BHATTACHARYA Nitai P BHATTACHARYA Subahshree BISWAS Tuhin Kanti MUKHERJEE Biswapati
• 来源期刊: 中国药理学报（英文版）
• 学科: 医学
• 关键词: 胎盘提取物 伤口愈合 动物疾病模型 半数致死量
• 年，卷（期）: 2001,（12）
• 所属期刊栏目: Original Research
• 页码范围: 1113-1116
• 页数: 4页
• 分类号: R96
• 语种: 英文

摘要

AIM: To study wound healing activity of the human placental extract (HPE) in rats. METHODS: Full thickness wounds were inflicted on depilated dorsum of Charles foster rats with 8 mt Acu-punch biopsy. The HPE was applied both at topical and im routes (2.5 mL/kg). Effects were compared on the basis of physical criteria, biochemical criteria, and histopathological study with respect to untreated control, vehicle control (1.5 %benzyl alcohol), and framycetin topical treated groups.RESULTS: Significant lowering of wound size (P ＜0.05), wound index ( P ＜ 0.05), and number of days required for complete healing ( P ＜ 0.01 ); significant gain in tensile strength ( P ＜ 0.01 ); appreciable increase of tissue DNA, total protein, and collagenesis were observed in HPE treated group. CONCLUSION:Human placental extract systematically helps collagenesis leading to potent healing of wounds.