依降钙素在SHR股动脉介导的收缩和舒张反应

• 作者: 藤本啓子 藤本征五
• 来源期刊: 中国药理学报(英文版)
• 学科: 医学
• 关键词: 乙酰胆碱 β肾上腺素受体 胆碱能受体 依降钙素 血管内皮 股动脉 一氧化氮 去甲肾上腺素 近交SHR大鼠
• 年，卷（期）: 2001,（7）
• 所属期刊栏目: 研究原著
• 页码范围: 595-602
• 页数: 8页
• 分类号: R96
• 语种: 英文

摘要

AIM: To study the effect of repeated systemic injections of elcatonin (a synthetic analog of eel calcitonin) on the responses of rat femoral artery preparation to vasoactive drugs and to determine subtypes of muscarinic cholinoceptors involved in acetylcholine ( ACh )-induced vasorelaxation in elcatonin-treated rats. METHODS: Spontaneously hypertensive rats (SHR) were treated sc with elcatonin, 0.5 and 5 U/kg, 3 times a week for 2 weeks. Responses to vasoactive drugs were determined in helically cut strips of femoral arteries of these rats. Schild plot data for muscarinic cholinoceptor antagonists were obtained on these vascular strips, using ACh as an agonist. RESULTS: Elcatonin did not alter systemic blood pressure and contractile responses of the femoral artery to KCl, norepinephrine, 5-hydroxytryptamine, and prostaglandin F2α. Elcatonin attenuated isoproterenol induced relaxation, increased ACh- and ATP-induced relaxations, and did not change relaxant responses to sodium nitroprusside and cromakalim in the femoral artery. Nitro L-arginine in the combination with tetrae thylammonium ( or charybdotoxin) completely abolished the relaxant response to ACh in the control but not in the elcatonin-treated arteries. The muscarinic cholinoceptor subtype involved in the ACh-induced relaxation was Ma in the elcatonin-treated as well as control SHR. CON CLUSION: Elcatonin decreases β-adrenoeeptor-mediated relaxation and increases M3 cholinoceptor-mediated relax ation in the SHR femoral artery. Although the ACh induced relaxation is explained by stimulated releases of nitric oxide (NO) and endothelium-derived hyperpolariz ing factor (EDHF) in the SHR artery, a NO- and EDHF independent mechanism in addition to NO and EDHF is responsible for the response to ACh in the femoral artery from the elcatonin-treated SHR.

作者信息

序号	姓名	单位	发文数	被引次数	H指数	G指数
1	藤本征五	名古屋市立大学医学院药理教研室	1	0	0.0	0.0