神经免疫对神经精神性和心理生理性紊乱的影响

• 来源期刊: 中国药理学报(英文版)
• 学科: 医学
• 关键词: 精神神经免疫学 精神病学 心理生理学 应激 神经免疫调节 细胞因子类
• 年，卷（期）: 2001,（7）
• 所属期刊栏目: 综述
• 页码范围: 577-587
• 页数: 11页
• 分类号: R96
• 语种: 英文

摘要

Top down central nervous system (CNS) influences on the immune system and bottom up immune system in fluences on the CNS take part in a complex feedforward and feedback loop which may be responsible for initiating events and perpetuating circumstances in the course of neuropsychiatric as well as immune system diseases. In this paper the authors examine the neuroendocrine neuroimmune stress response system, the concept of au toimmunoregulation, and recent studies of immune and pharmacological dysregulation in neuropsychiatric and psychosomatic illnesses. The authors review the recent English-language literature on these subjects. Support for the hypothesis that macrophages play an important role in neurodevelopment and in the pathophysiology of vari ous neuropsychiatric conditions is found. The interplay between neurologic and immune systems may help to un cover the pathophysiologies of certain neuropsychiatric systems. This may provide new strategies for pharmaco logic anti-inflammatory treatments. The monocyte/ macrophage, which crosses the blood-brain barrier is an essential candidate cell in the study of psychoneuroim munology.