IMPACT OF POLY CHLORINATED BIPHENYL (AROCLOR 1254) AND VITAMIN C ON ANTIOXIDANT SYSTEM OF RAT VENTRAL PROSTATE

• 来源期刊: 亚洲男性学杂志(英文版)
• 学科: 工学
• 年，卷（期）: 2004,（1）
• 页码范围: 19-22
• 页数: 4页
• 分类号: TQ460
• 语种: 中文

摘要

Aim: To evaluate the effect of polychlorinated biphenyls (PCB) and vitamin C on ventral prostatic antioxidant system in adult male rats. Methods: A group of 20 adult male rats were administered ip Aroclor 1254 in corn oil at a dose of 2 mg·kg-1·day-1 for 30 days. Ten control rats were administered only the vehicle. After 30 days the treated rats were divided at random into 2 sub-groups of 10 animals each. One sub-group received vitamin C at a dose of 500 mg·kg-1·day-1 for 10 days. The other group was maintained as Aroclor 1254 control. Twenty-four hours after the last treatment the rats were killed by decapitation. Ventral prostatic homogenate was prepared and used for the estimation of enzymatic antioxidants, including superoxide dismutase (SOD), catalase (CAT) and glutathione-S-transferase (GST) and hydrogen peroxide (H2O2), lipid peroxidation (LPO) and prostatic acid phosphatase. The serum levels of total T3, total T4, TSH, testosterone and estradiol were also assayed. Results: The body weight and