Study on Hyper-radiosensitivity Effect of Human Hepatoma SMMC-7721 Cells Exposed to Low Dose γ-rays

• 作者: Jin Xiaodong Li Qiang Li Wenjian Wang Jufang Guo Chuanling Hao Jifang
• 来源期刊: 近代物理研究所和兰州重离子加速器实验室年报：英文版
• 学科: 工学
• 关键词: 低剂量电离辐射 细胞水平 HYPER 放射敏感性 肝癌 显示 存活曲线 线性二次型
• 年，卷（期）: 2004,（1）
• 页码范围: 94
• 页数: 1页
• 分类号: TP317.4

摘要

<正>Studies on biological response to ionizing radiation at low doses have been a hot spot recently since relevant methods have become available that allow accurate measurement of clonogenic survival fraction at very low levels of cell killing. The results of using these methods show that the linear-quadratic (LQ) equation can not describe the cell-survival curve in the low dose region correctly. The surviving data suggest that in human tumor cell lines increased cell killing per unit dose occurs when the doses are blow 1 Gy. This phenomenon is termed low dose hyper-radiosensitivity (HRS), and it is followed by increased radiation resistance (IRR) above a certain dose. The purpose of this study was to examine the low-dose sensitivity of human hepatoma SMMC-7721 cells exposed to low-LET γ-rays.