Noradrenergic mechanism in the regulation of seizures in GEPR.

• 作者: Kwang-HoKo Dong-OokSeo Jae-RyunRyu Chan-YoungShin
• 来源期刊: 中国药理通讯
• 学科: 医学
• 关键词: 去甲肾上腺素 遗传性癫痫 大鼠 动物模型
• 年，卷（期）: 2004,（2）
• 页码范围: 3-4
• 页数: 2页
• 分类号: R742.1

摘要

Genetically epilepsy prone rat (GEPR) is a model of generalized tonic/clonic epilepsy and a useful tool in the understanding of basic mechanisms of human epilepsy. GEPR is susceptible to audiogenic seizure, hyperthermia induced seizure,and has lower threshold for electrical and chemical stimuli. Several strains of GEPR, from GEPR-3 to GEPR-9, are available depending on the degree of the intensity of audiogenic seizure.