Study on the Association between Body Weight and Insulin Resistance in Essential Hypertension , X- syndromes and Type- 2 Diabetes

• 作者: 徐岩 王爱玲 陈森
• 来源期刊: 中华临床医学杂志
• 学科: 医学
• 关键词: Ⅱ型糖尿病 胰岛素抵抗 体重 高血压
• 年，卷（期）: zhlcyxzz_2004,（9）
• 页码范围: 8-10
• 页数: 3页
• 分类号: R587.1

摘要

Objective To prove the hypothesis that there are associations between body weight and insulin resistance in essential hypertension, X- syndromes and type- 2 diabetes. Methods We examined the body mass index (BMI) and insulin sensitve index (ISI) among 70 hypertensives, 39 X - syndromes, 33 type - 2 diabetes and 46 controls. To observe the relations between the degrees of obesity and LSI in all study groups. Seventy patients with hypertension [70 hypertensives, 48 men and 22 women, mean age (69.3 + 6.7) years], 39X-syndromes [27 men and 12 women, mean age (66.4+6.2) years], 33 type- 2 diabetes [21 men and 12 women, mean age (68.7±7.3) years], and 46 healthy controls [36 men and 10 women, mean age (66.1 + 6.6) years]. During study period, no patients died. Results All patients of hypertensives, X - syndromes and type - 2 diabetes have insulin resistance, BMI in all patients was singnificantly higher than in controls. The levels of blood glucose and insulin were significantly higher in obese hypertensives (BMI≥25kg/m^2 ) than in those (BMI<25kg/m^2 ). LSI in obese subjects with hypertension and X - syndrome were significantly lower than in no - obesities. ISI was related to BMI. Conclusion There were insulin resistance in patients of hypertension and X - syndrome. Obesity was related to lower ISI. Obesity may be an important risk factor for insulin resistance of essential hypertension and X - syndrome. ISI and BMI may be simple and specific clinical predictor for hypertension and X - syndrome patients.