Further evidence for the roles of 5-lipoxygenase and cysteinyl leukotriene receptors in cerebral ischemic injury

• 作者: Wei-pingZHANG Qiu-fuGE San-huaFANG YuZHOU Guo-liangYU Meng-lingWANG ZhongCHEN Er-qingWEI
• 来源期刊: 中国药理通讯
• 学科: 医学
• 关键词: 5-脂肪氧合酶 半胱氨酰基 白细胞三烯受体 大脑 5-LOX CysLT1
• 年，卷（期）: 2005,（2）
• 页码范围: 25-26
• 页数: 2页
• 分类号: R971

摘要

Arachidonic acid-metabolizing enzyme 5-lipoxygenase (5-LOX) produces pro-inflammatory mediators:leukotrienes (including cysteinyl leukotrienes, CysLTs). 5-LOX and CysLTs are involved in the pathophysiological process after brain injury, and the actions of CysLTs are mediated via activation of their receptors, CysLT1 and CysLT2. We have recently reported the expressions of 5-LOX, CysLT1 and CysLT2 in human brains with traumatic injury and tumors, and short-term neuroprotective effects of Cys-LT1 antagonists in stroke models of rats and mice.