Relationship between Protein Expression Levels and Messenger Ribonucleic Acid with Shine-dalgarno Local Structure

• 作者: Zhou Qingming Zhang Hong
• 来源期刊: 近代物理研究所和兰州重离子加速器实验室年报：英文版
• 学科: 生物学
• 关键词: 信使核糖核酸 蛋白质表达 局部结构 服务 水 碱基配对 蛋白质折叠 mRNA
• 年，卷（期）: 2005,（1）
• 页码范围: 94
• 页数: 1页
• 分类号: Q522.2

摘要

<正>Loose base pairing of the Shine-dalgarno (SD) sequence with other regions of the Messenger Ribonucleic Acid (mRNA) is strongly affected by polyamine stimulation and translates more protein. In contrast with the tense base pairing, the protein is less translated. We present a simple mathematical model (In (fold) =[1n(m) -kG0] +kG, in this equation, fold presents the protein expression level, m and k are the proportionality constant, G0 is the least free energy of the local SD structure when the SD is exposed and G