钙激活的氯通道与哮喘气道粘液过度分泌

• 作者: 刘剑波 张珍祥 徐永健
• 来源期刊: 中国病理生理杂志
• 学科: 医学
• 关键词: 钙 氯通道 粘蛋白类 粘液 哮喘
• 年，卷（期）: 2005,（6）
• 所属期刊栏目: 综述
• 页码范围: 1239-1241,1245
• 页数: 4页
• 分类号: R363
• 字数: 4166字
• 语种: 中文
• DOI: 10.3321/j.issn:1000-4718.2005.06.048

摘要

Ca2+-activated chloride channels (CaCC, CLCA) are a new family of chloride channels discovered recently, which are related to Ca2+-sensitive chloride ions transport, and there were several members identified currently in different biologic bodies. New studies have shown that its member gob-5 in murine （its human counterpart is CaCC1） plays a pivotal role in airway goblet cell metaplasia, mucus overproduction, MUC5AC gene expression as well as airway hyperresponsiveness (AHR) in asthma, and is a key molecule in the induction of murine asthma and an asthma-related gene. Inhibition of their function and/or their signaling pathway may therefore provide a new therapeutic strategy for asthma.

作者信息

序号	姓名	单位	发文数	被引次数	H指数	G指数
1	张珍祥	华中科技大学同济医学院同济医院卫生部呼吸疾病重点实验室	243	1952	19.0	30.0
2	徐永健	华中科技大学同济医学院同济医院卫生部呼吸疾病重点实验室	297	2251	20.0	31.0
3	刘剑波	华中科技大学同济医学院同济医院卫生部呼吸疾病重点实验室	9	38	4.0	5.0