Structure and Function of the NS1 Protein of Influenza A Virus

• 来源期刊: 生物化学与生物物理学报（英文版）
• 关键词: influenza A virus NS1A protein RNA-binding domain effector domain dimer resistance antiviral response
• 年，卷（期）: 2007,（3）
• 页码范围: 155-162
• 页数: 8页
• 语种: 英文

摘要

The avian influenza A virus currently prevailing in Asia causes fatal pneumonia and multiple organ failure in birds and humans.Despite intensive research,understanding of the characteristics of influenza A virus that determine its virulence is incomplete.NS1A protein,a non-structural protein of influenza A virus,was reported to contribute to its pathogenicity and virulence.NS1A protein is a multifunctional protein that plays a significant role in resisting the host antiviral response during the influenza infection.This review briefly outlines the current knowledge on the structure and function of the NS1A protein.