Biological characteristics of dengue virus and potential targets for drug design

• 来源期刊: 生物化学与生物物理学报(英文版)
• 关键词: dengue virus NS3 protease polyprotein processing drug target
• 年，卷（期）: 2008,（2）
• 页码范围: 91-101
• 页数: 11页
• 语种: 英文

摘要

Dengue infection is a major cause of morbidity in tropical and subtropical regions, bringing nearly 40% of the world population at risk and causing more than 20,000 deaths per year. But there is neither a vaccine for dengue disease nor antiviral drugs to treat the infection. In recent years, dengue infection has been particularly prevalent in India, Southeast Asia, Brazil, and Guangdong Province, China. In this article, we present a brief summary of the biological characteristics of dengue virus and associated flaviviruses, and outline the progress on studies of vaccines and drugs based on potential targets of the dengue virus.